Evidence Of Significant Differences Research Articles

31 Effects of dietary standardized ileal digestible (SID) lysine (Lys) levels and dietary SID tryptophan to Lys ratios on growth performance and behavior of late-nursery to finish maternal barrows

Abstract The objective was to determine the effects of dietary standardized ileal digestible (SID) lysine (Lys) levels and SID tryptophan (Trp) to Lys ratios on growth performance and behavior of late-nursery to finish maternal barrows. A total of 2,293 barrows (PIC Camborough, initially 11.9 ± 0.35 kg) were used in this trial with 96 mixed-sex pens and 23 to 25 pigs/pen. There was a total of 6 dietary phases: P1:11.9-29.5 kg; P2:29.5-49.6 kg; P3:49.6-62.6 kg; P4:62.6-80.3 kg; P5:80.3-103.3 kg; and P6:103.3-137.8 kg. Pens were blocked by body weight and randomly allotted to 1 of 6 treatments:T1: 100% Lys (dietary SID Lys levels meet PIC SID Lys recommendation) and 21.0% of SID Trp:Lys ratio; T2: 100% Lys and 18.5% of SID Trp:Lys ratio; T3: 100% Lys and 16.0% of SID Trp:Lys ratio; T4: 80% Lys (dietary SID Lys levels meet 80% of PIC SID Lys recommendation) and 21.0% of SID Trp:Lys ratio; T5: 80% Lys and 18.5% of SID Trp:Lys ratio; and T6: 80% Lys and 16.0% of SID Trp:Lys ratio for P1-P2 and then 100% Lys and 18.5% of SID Trp:Lys ratio for P3-P6. Ear lesion (EL) was monitored during P2-P5. Data were analyzed using a linear mixed model in R Studio (Version 3.5.2, R Core Team; Vienna, Austria). Pigs fed T1 and T2 showed improved average daily gain than T6 (P < 0.05), with other treatments intermediate (Table 1). Pigs fed T2 showed improved average daily feed intake as compared with T6 (P < 0.05), with other treatments intermediate. There was no evidence for significant difference on feed-to-gain ratio or mortality. Removal was significantly greater for pigs fed T6 compared with all other treatments (P < 0.05). Pigs fed T2 had significantly greater hot carcass weight than T4, with other treatments intermediate. There was no evidence for significant differences on carcass yield or lean percentage. Pig fed T6 had significantly greater incidence of EL in P2 than all other treatments (P < 0.05). Pigs fed T4 and T6 had greater incidence of EL in P3 than T1 (P < 0.05), with other treatments intermediate. Pigs fed T5 and T6 had significantly greater incidence of EL in P4 than T1, T2, and T3 (P < 0.05), with T4 intermediate. During P5, pigs fed T4 and T5 had the greatest incidence of EL (P < 0.05), while pigs fed T6 had significant greater incidence of EL than T3 (P < 0.05), with T1 and T2 intermediate. In conclusion, dietary SID Lys and SID Trp:Lys ratio less than PIC recommendation during late-nursery-to-grower phase resulted in compromised overall growth performance of maternal barrows, even with restored dietary SID Lys and SID Trp:Lys levels in finish phase. Dietary SID Lys level and/or SID Trp:Lys ratios lower than PIC recommendation may result in greater incidence of aggression behavior in maternal barrows.

Disambiguating ambiguity: A comparative analysis of lexical decision-making in native and non-native English speakers

Making lexical decisions to disambiguate multiple-meaning words or senses provides clear evidence of word recognition, processing systems and representation in the mental lexicon. This comparative study explores non-native English speakers’ and native English speakers’ cognitive mechanisms employed in phonological and lexical ambiguity resolution embedded in auditory and visual utterances. English proficiency and vocabulary tests and two lexical decision tests were conducted with 35 EFL undergraduate students and four native English monolingual speakers. The effects of factors such as L2 proficiency and familiarity on ambiguity resolution  in addition to the resolution techniques employed were also explored. Our findings suggest that the differences in disambiguating L2 words among native English speakers and non-native English speakers might indicate different comprehension, representation and processing patterns. The ambiguity type most likely has a major role in determining the diverse phenomenon of ambiguity resolution.  More specifically, there was evidence of significant differences in homophone use, metaphorical polysemy and homonym ambiguity resolution between the two groups, excluding metonymous polysemy. Homophones and polysemy were the least problematic and challenging lexical ambiguity types unlike homonymy for the non-native group. Other results also revealed the positive effects of L2 proficiency and L2 word familiarity on ambiguity resolution. Thus, this study also has important implications considering the vital role of vocabulary in L2 competence and knowledge.

Mental Disorders and Suicidality by Sexual Orientation Status Among First-Year College Students in France

ABSTRACT Studies indicate that non-heterosexual young adults experience higher rates of mental health problems in various settings. This study seeks to further explore these associations, distinguishing heterosexual, gay/lesbian, bisexual and individuals questioning their sexual identity. Data were drawn from the French portion of the World Mental Health International College Student survey initiative (n = 3,545). Logistic regressions were performed to estimate the associations of sexual orientation with 12-month mental disorders and suicidal ideation and behaviors. Overall, 81.6% (n = 2,894) of students identified as heterosexual, 2.9% (n = 103) as gay/lesbian, 8.5% (n = 302) as bisexual and 6.9% (n = 246) stated questioning their sexual orientation. In adjusted models, compared to heterosexuals, students identifying as bisexual reported greater odds of major depression, panic disorder, drug use disorder and suicidality, gay/lesbian students were more likely to present with panic disorder, suicidal ideation and plans, and students questioning their sexual orientation were at greater risk for generalized anxiety disorder, suicidal ideation, and plans. The study confirmed higher rates for mental health disorders for non-heterosexual young adults, with little evidence of significant differences between minority subgroups.

Penoscrotal approach for inflatable penile prosthesis implant: why it should be preferred.

Inflatable penile prosthesis are the definitive treatment for erectile dysfunction. The two most used surgical approaches to position the implants are the penoscrotal and the infrapubic. Current trends showed that the penoscrotal approach is extensively preferred however, there is not conclusive evidence demonstrating the superiority of one technique over the other. The aim of this review is to summarize the scientific evidence available and to underline strengths and weaknesses of the two techniques. We conducted a comprehensive search of MEDLINE, Cochrane Library, and National Center for Biotechnology Information PubMed to identify relevant published articles. The included studies had to explicitly examine the use of three-piece inflatable penile prosthesis with a focus on the surgical access method and complications. Twenty-six articles were included in the review: seven narrative reviews, five retrospective observational studies, five prospective observational studies, and nine mixed methodology studies. The most frequent approach was the penoscrotal, which was also found more comfortable (RG1) by the operators in one study. The infrapubic approach lasts less and one study demonstrated higher satisfaction by the patients. There is no evidence of significant differences in complications among the penoscrotal and infrapubic approaches. While the infrapubic approach is faster and patients were more satisfied, the penoscrotal approach is the most used by far. This is likely related to the more straightforward procedure through this access and the excellent surgical field exposure. For these reasons, it is also preferred in the most complex cases.

Reorganization of functional brain networks in healthy aging and mild cognitive impairment during the visual motion discrimination task

AbstractBackgroundPreviously, we reported that there was significant decrease in spectral power for eyes‐closed resting state EEG (rsEEG) immediately following a visual motion discrimination task as compared to before task engagement in older adults – the so‐called Task Aftereffect (TA). Further, we have also shown that rsEEG TA differentiated between older adults with mild cognitive impairment (MCI) and healthy controls (HC), with the MCI participants showing more integrated topology in post‐ as compared to pre‐cognitive task rsEEG. We now report EEG topological changes during task performance with regards to: changes in functional network organization from the beginning to the end of the task and evidence for significant differences in topology between MCI patients and HC.MethodWe studied a sample of community dwelling African American older participants over age 60 years, with consensus‐based diagnosis for 51 HC and 39 MCI. EEG epochs extracted for analysis were two‐second epochs before the motion onset of each stimulus at the beginning, middle, and end of the full task. Functional connectivity between channels was assessed by the phase lag index. Minimum spanning tree (MST) was used to characterize network topology.ResultTime effect was confirmed, as network organization in all participants significantly improved with task progression. On average, brain topology became more integrated with higher leaf fraction and smaller average eccentricity. Moreover, our results show differences between groups in MST parameters over the whole task. Most differences were observed at the earliest timepoint at lower frequency range (theta and lower alpha) where average eccentricity was significantly decreased. Leaf fraction and maximal betweenness centrality were significantly increased in the MCI group as compared to HC.ConclusionThe change in network organization suggests that MCI require greater network integration across brain areas before repeated motion onset presentations. This could reflect compensatory brain mechanisms, especially as both groups did not show significant differences in task performance. These findings enhance our understanding of the functional brain network organization immediately prior to repeated responses in a visual perceptual task in MCI compared to HC. This emphasizes the potential for using graph‐theoretic measures as a valid tool for the early detection of cognitive impairment.

Correspondence of Somatic Cell Counts in Bulk-Tank Milk to Prevalence of Subclinical Mastitis in Sheep Flocks.

The objective of the present study was to propose thresholds of somatic cell counts in bulk-tank milk indicative of the prevalence of subclinical mastitis in a flock. A retrospective analysis was performed on data from a longitudinal survey of subclinical mastitis in Greece, in which the prevalence of subclinical mastitis in 12 flocks sampled four times throughout a milking period was evaluated by collecting milk samples from individual ewes for bacteriological and cytological testing; further, cell counts in the bulk-tanks of the farms were also measured during the visits. Four cohorts were created: A, with cell counts in the bulk-tank milk between 0.100 × 106 and 0.400 × 106 cells mL-1, B, with cell counts between 0.400 × 106 and 650 × 106 cells mL-1, C, with cell counts between 0.650 × 106 and 900 × 106 cells mL-1, and D, with SCC between 0.900 × 106 and 1.450 × 106 cells mL-1. There was a significant positive correlation between prevalence of the infection in the flocks and somatic cell counts in bulk-tank milk on the same sampling occasion (p < 0.0001). There was also evidence of significant differences between the four cohorts in the mean prevalence rate of the infection (p < 0.0001). Ninety-five percent confidence intervals of the prevalence of subclinical mastitis according to the somatic cell counts in the bulk-tank milk were calculated as follows: for cohort A, 8.7% to 12.1%, for B, 12.4% to 19.4%, for C, 22.5% to 30.8% and for D, 27.3% to 45.3%. The information that may be thus obtained can be useful in guiding the implementation of various health management procedures for mastitis control in sheep flocks, with no need to perform milk sample collection from ewes and subsequent laboratory examinations.

Empagliflozin in patients admitted to hospital with COVID-19 (RECOVERY): a randomised, controlled, open-label, platform trial

Empagliflozin has been proposed as a treatment for COVID-19 on the basis of its anti-inflammatory, metabolic, and haemodynamic effects. The RECOVERY trial aimed to assess its safety and efficacy in patients admitted to hospital with COVID-19. In the randomised, controlled, open-label RECOVERY trial, several possible treatments are compared with usual care in patients hospitalised with COVID-19. In this analysis, we assess eligible and consenting adults who were randomly allocated in a 1:1 ratio to either usual standard of care alone or usual standard of care plus oral empagliflozin 10 mg once daily for 28 days or until discharge (whichever came first) using web-based simple (unstratified) randomisation with allocation concealment. The primary outcome was 28-day mortality; secondary outcomes were duration of hospitalisation and (among participants not on invasive mechanical ventilation at baseline) the composite of invasive mechanical ventilation or death. On March 3, 2023 the independent data monitoring committee recommended that the investigators review the data and recruitment was consequently stopped on March 7, 2023. The ongoing RECOVERY trial is registered with ISRCTN (50189673) and ClinicalTrials.gov (NCT04381936). Between July 28, 2021 and March 6, 2023, 4271 patients were randomly allocated to receive either empagliflozin (2113 patients) or usual care alone (2158 patients). Primary and secondary outcome data were known for greater than 99% of randomly assigned patients. Overall, 289 (14%) of 2113 patients allocated to empagliflozin and 307 (14%) of 2158 patients allocated to usual care died within 28 days (rate ratio 0·96 [95% CI 0·82-1·13]; p=0·64). There was no evidence of significant differences in duration of hospitalisation (median 8 days for both groups) or the proportion of patients discharged from hospital alive within 28 days (1678 [79%] in the empagliflozin group vs 1677 [78%] in the usual care group; rate ratio 1·03 [95% CI 0·96-1·10]; p=0·44). Among those not on invasive mechanical ventilation at baseline, there was no evidence of a significant difference in the proportion meeting the composite endpoint of invasive mechanical ventilation or death (338 [16%] of 2084 vs 371 [17%] of 2143; risk ratio 0·95 [95% CI 0·84-1·08]; p=0·44). Two serious adverse events believed to be related to empagliflozin were reported: both were ketosis without acidosis. In adults hospitalised with COVID-19, empagliflozin was not associated with reductions in 28-day mortality, duration of hospital stay, or risk of progressing to invasive mechanical ventilation or death so is not indicated for the treatment of such patients unless there is an established indication due to a different condition such as diabetes. UK Research and Innovation (Medical Research Council) and National Institute of Health Research (MC_PC_19056), and Wellcome Trust (222406/Z/20/Z). For the Nepali, Hindi, Indonesian (Bahasa) and Vietnamese translations of the abstract see Supplementary Materials section.

Comparative Analysis between 3D-Printed Models Designed with Generic and Dental-Specific Software.

A typodont was digitized with an intraoral scanner and the models obtained were exported in STL format to four different softwares (Autodesk MeshMixer 3.5, Exocad Dental, Blender for dental, and InLAB). The STL files obtained by each software were materialized using a 3D printer. The printed models were scanned and exported in STL files, with which six pairs of groups were formed. The groups were compared using analysis software (3D Geomagic Control X) by superimposing them in the initial alignment order and using the best fit method. There were no significant differences between the four analyzed software types; however, group 4, composed of the combination of D-CAD (Blender-InLAB), obtained the highest average (-0.0324 SD = 0.0456), with a higher accuracy compared to the group with the lowest average (group 5, composed of the combination of the Meshmixer and Blender models), a generic software and a specific software (0.1024 SD = 0.0819). Although no evidence of significant difference was found regarding the accuracy of 3D models produced by G-CAD and D-CAD, combinations of groups where specific dental design software was present showed higher accuracy (precision and trueness). The comparison of the 3D graphics obtained with the superimposition of the digital meshes of the printed models performed with the help of the analysis software using the best fit method, replicating the same five reference points for the six groups formed, evidenced a greater tolerance in the groups using D-CAD.

East vs West: Satisfaction With Knowledge Sharing Among Millennials

Knowledge sharing (KS) among individuals working together is complex and has an effect on their satisfaction. We adopt the self-determination theory and the theory of reasoned action to examine the relationship between millennials’ characteristics, KS and the resulting satisfaction. Using a mixed-method approach we address the antecedents of satisfaction in KS for 213 millennials attending Master programs in management at Polish and Portuguese business schools. The quantitative results show that knowledge characteristics influence KS as well as the fear of losing power due to KS. Knowledge complementarity and knowledge complexity positively contribute to KS. Knowledge complexity increases the fear of losing power due to KS, while knowledge complementarity decreases it, probably because individuals recognize complex knowledge as a more valuable one. The qualitative findings corroborate the quantitative results. Knowledge complementarity’s presence alone leads to KS, while its absence and knowledge complexity’s existence generate the fear of losing power. KS behavior and not being afraid of losing power due to KS lead to satisfaction from KS. The integration of both outputs is robust since quantitative results and qualitative findings converge: a) KS results from knowledge complementarity: knowledge complementarity relates positively to KS, which is consistent with a high level of knowledge complementarity providing a sufficient condition for a high level of KS; b) The fear of losing power results from the absence of knowledge complementarity and the existence of knowledge complexity, which is consistent with knowledge complementarity relating negatively to the fear of losing power and knowledge complexity relating positively to the fear of losing power; c) Satisfaction occurs when KS exists and the fear of losing power is absent, which is in line with KS relating positively to satisfaction and the fear of losing power due to KS relating negatively to satisfaction. Furthermore, the results show that millennial students’ satisfaction from KS is really a behavioral question and not a cultural one since there is no evidence of significant differences between the two subsamples. Millennials behave uniformly on Europe’s western and eastern ends.

An empirical study to evaluate the impact of mindfulness on helpdesk employees

Purpose: Mindfulness is a meditation technique whose main goal involves maintaining a calm mind and training attention by focusing only on a single thing (the support) at a time; this support is usually the practitioner's breathing. The practice of mindfulness aims to improve concentration and attention, which has proven useful in knowledge-intensive and stressful work environments like technological companies. This article aims to find empirical evidence on the positive effect of the practice of mindfulness on a sample of 56 helpdesk employees working for a consulting and information technology company (Accenture) with respect to: i) their attention awareness; ii) a set of key performance indicators (KPIs); and iii) the perceived benefits of mindfulness. Method: Of the 56 recruited employees, 29 worked as managers, and 27 worked as agents answering phone calls to solve software issues of the main information system of the Andalusian Health Service, a public organization with more than 115,000 employees. Mindfulness (the treatment) was applied to 26 subjects, while the other 30 subjects were the control group. For all subjects, their attention awareness was measured using the MAAS scale. Results: Both helpdesk managers and agents significantly improved their attention awareness with respect to the control group. Regarding organizational KPIs, in general, no evidence of significant differences between groups was detected, apart from the fact that the number of phone calls answered was significantly lower in the mindfulness group, probably due to a longer call duration caused by a deliberate better attention to the customer, but without degrading any other KPI. With respect to the perceived benefits of the treatment, the questionnaires show relevant improvements perceived by most employees after practicing mindfulness.Conclusions: We confirm that mindfulness improves attention awareness and benefits the working and personal life of helpdesk employees. However, further research is needed to identify a clear impact on productivity.

Rural and Agricultural Natural Disaster Stress and Recovery: A Comparison

ABSTRACT This study used a novel survey instrument to evaluate the hypothesis that U.S. agricultural producers have significantly different stress and recovery experiences following acute-onset natural disaster compared to their non-agricultural counterparts. Participants were recruited through local organizations and targeted email and social media in communities in Arkansas and Nebraska that had experienced violent tornadoes in 2014 and/or severe flooding in 2019. The survey instrument incorporated the Brief Resilience Scale, the Revised Impact of Event Scale referencing two time points, the Posttraumatic Growth Inventory-Short Form, and original questions. Demographic, exposure, stress, and recovery measures were analyzed in SAS with Chi-square tests, t-tests, Wilcoxon tests, and multiple linear regression modeling to test for differences between agricultural and non-agricultural groups in resilience, event exposure, stress symptoms in the week after the event, stress symptoms in the month before the survey, a calculated recovery ratio, and posttraumatic growth. Analysis sample (N = 159) contained 20.8% agricultural occupation, 71.1% female, and 49.1% over age 55. No significant differences were found between agricultural and non-agricultural participants when comparing resilience, stress, or recovery ratio measures. Unadjusted posttraumatic growth score was significantly lower in the agriculture group (P = .02), and an occupation group by sex interaction was significantly associated with posttraumatic growth score (P = .02) when controlled for number of initial posttraumatic stress symptoms in the adjusted model, with agricultural women showing lower growth. Overall, there was no evidence of significant difference in disaster stress and recovery between agricultural and rural, non-agricultural groups in this study. There was some evidence that women in agriculture may have lower levels of recovery. Data indicated that rural residents continue to experience posttraumatic-type symptoms up to 8 years beyond the acute-onset natural disaster events. Communities should include strategies to support mental and emotional health in their preparedness, response, and recovery plans with intentional inclusion of agricultural populations.

Efficacy of rFIXFc versus N9-GP Prophylaxis in Patients with Hemophilia B: Matching-Adjusted Indirect Comparison of B-LONG and PARADIGM 2 Trials.

For patients with hemophilia B, extended half-life factor IX (FIX) products are available for prophylaxis and for treating bleeds. Different methods are used to extend the half-lives of recombinant FIX Fc fusion protein (rFIXFc) and nonacog beta pegol (N9-GP). This affects their biodistribution and plasma FIX levels, although differences do not always correlate with clinical outcomes. A matching-adjusted indirect comparison (MAIC) of prophylaxis with rFIXFc and N9-GP was performed, based on licensed dosing in the European Union. Combined rFIXFc data from the weekly and individualized interval prophylaxis arms of the B-LONG clinical trial, and N9-GP data from the 40 IU/kg once-weekly prophylaxis arm of PARADIGM 2 were used in a MAIC. Individual patient data for rFIXFc (n=87) were matched to aggregated data for N9-GP (n=29). Estimated annualized bleeding rates (ABRs) for rFIXFc were recalculated using a Poisson regression model with adjustment for over-dispersion, and compared with ABRs reported for N9-GP, using incidence rate ratios (IRRs) with 95% confidence interval (CI). There was no evidence of significant differences in estimated ABRs between prophylaxis with rFIXFc and N9-GP. Analysis of pooled rFIXFc weekly and interval-adjusted dosing compared with N9-GP 40 IU/kg once weekly produced estimated ABRs of 2.59 versus 2.51 (IRR 1.03; 95% CI 0.56-1.89), as well as 1.34 versus 1.22 (IRR 1.10; 95% CI 0.42-2.91) and 1.13 versus 1.29 (IRR 0.88; 95% CI 0.47-1.63) for overall, spontaneous, and traumatic bleeding events, respectively. The study did not reveal any significant differences in the efficacy of rFIXFc and N9-GP prophylaxis. Given differences in trough levels (rFIXFc dosing was targeted to achieve a trough 1-3 IU/dL above baseline versus a reported estimated N9-GP mean trough of 27.3 IU/dL), interpreting plasma FIX levels as potential surrogate efficacy markers requires consideration of compound-specific pharmacokinetic profiles.

Proximal Instructions for Use Violations in Elective Endovascular Aneurysm Repair in the Vascular Quality Initiative: Retrospective Analysis.

Endovascular aneurysm repair (EVAR) is often attempted in patients with marginal anatomy. These patients' midterm outcomes are available in the Vascular Quality Initiative for analysis. Retrospective analysis of prospectively collected data in the Vascular Quality Initiative from patients who underwent elective infrarenal EVAR between 2011 and 2018. Each EVAR was identified as either on- or off-instructions for use (IFU) based on aortic neck criteria. Multivariable logistic regression models were used to assess associations between aneurysm sac enlargement, reintervention, and type Ia endoleak with IFU status. Kaplan-Meier time-to-event models estimated reintervention, aneurysm sac enlargement, and overall survival. We identified 5,488 patients with at least 1 follow-up recorded. Those treated off-IFU included 1,236 patients ([23%] mean follow-up 401 days) compared with 4,252 (77%) treated on-IFU (mean follow-up 406 days). There was no evidence of significant differences in crude 30-day survival (96% vs 97%; p = 0.28) or estimated 2-year survival (97% vs 97%; log-rank p = 0.28). Crude type Ia endoleak frequency was greater in patients treated off IFU (2% vs 1%; p = 0.03). Off-IFU EVAR was associated with type Ia endoleak on multivariable regression model (odds ratio 1.84 [95% CI 1.23 to 2.76]; p = 0.003). Patients treated off IFU vs on IFU experienced had increased risk of reintervention within 2 years (7% vs 5%; log-rank p = 0.02), a finding consistent with results from the Cox modeling (hazard ratio 1.38 [95% CI 1.06 to 1.81]; p = 0.02). Patients treated off IFU were at greater risk for type Ia endoleak and reintervention, although they had similar 2-year survival compared with those treated on IFU. Patients with anatomy outside IFU should be considered for open surgery or complex endovascular repair to reduce the probability for revision.

Soil carbon dioxide (CO2) fluxes in permanent upslope pasture and downslope riparian buffers with varying vegetation

AbstractBackgroundRiparian buffers are primarily implemented for their water quality functions in agroecosystems. Their location in the agricultural landscape allows them to intercept and process pollutants from immediately adjacent agricultural land. Vegetated riparian buffers recycle soil organic matter, which elevates soil carbon (C), which upon processing, processes and releases carbon dioxide (CO2). The elevated soil C and seasonally anoxic environments associated with riparian buffers promote denitrification and fermentation, further increasing soil CO2 production.AimAgainst this context, a replicated plot‐scale experiment was established at North Wyke, UK, to measure the extent of soil CO2 emissions in permanent pasture served by grass, willow, and woodland riparian buffers, as well as a no‐buffer control.MethodsSoil CO2 was measured using the static chamber technique in conjunction with soil and environmental variables between June 2018 and February 2019.ResultsCumulative soil CO2 fluxes were in the descending order: woodland riparian buffer; 11,927.8 ± 1987.9 kg CO2 ha–1 &gt; no‐buffer control; 11,101.3 ± 3700.4 kg CO2 ha–1 &gt; grass riparian buffer; 10,826.4 ± 2551.8 kg CO2 ha–1 &gt; upslope pasture; 10,554.6 ± 879.5 kg CO2 ha–1 &gt; willow riparian buffer; 9294.9 ± 1549.2 5 kg CO2 ha–1. There was, however, no evidence of significant differences among all treatments of the current study.ConclusionsDespite the lack of significant differences, the results from our short‐term study show that the woodland riparian buffer had relatively larger soil CO2 emissions than the remainder of the other riparian buffers and the upslope pasture it serves. Our short‐term findings may be useful in developing soil CO2 mitigation strategies through careful selection of riparian buffer vegetation and may be useful in calibrating mechanistic models for simulating such emissions from similar agro systems.

Acute Toxicity of Hypofractionated and Conventionally Fractionated (Chemo)Radiotherapy Regimens for Bladder Cancer: An Exploratory Analysis from the RAIDER Trial

AimsAdding concurrent (chemo)therapy to radiotherapy improves outcomes for muscle-invasive bladder cancer patients. A recent meta-analysis showed superior invasive locoregional disease control for a hypofractionated 55 Gy in 20 fractions schedule compared with 64 Gy in 32 fractions. In the RAIDER clinical trial, patients undergoing 20 or 32 fractions of radical radiotherapy were randomised (1:1:2) to standard radiotherapy or to standard-dose or escalated-dose adaptive radiotherapy. Neoadjuvant chemotherapy and concomitant therapy were permitted. We report exploratory analyses of acute toxicity by concomitant therapy-fractionation schedule combination. Materials and methodsParticipants had unifocal bladder urothelial carcinoma staged T2-T4a N0 M0. Acute toxicity was assessed (Common Terminology Criteria for Adverse Events) weekly during radiotherapy and at 10 weeks after the start of treatment. Within each fractionation cohort, non-randomised comparisons of the proportion of patients reporting treatment emergent grade 2 or worse genitourinary, gastrointestinal or other adverse events at any point in the acute period were carried out using Fisher's exact tests. ResultsBetween September 2015 and April 2020, 345 (163 receiving 20 fractions; 182 receiving 32 fractions) patients were recruited from 46 centres. The median age was 73 years; 49% received neoadjuvant chemotherapy; 71% received concomitant therapy, with 5-fluorouracil/mitomycin C most commonly used: 44/114 (39%) receiving 20 fractions; 94/130 (72%) receiving 32 fractions. The acute grade 2+ gastrointestinal toxicity rate was higher in those receiving concomitant therapy compared with radiotherapy alone in the 20-fraction cohort [54/111 (49%) versus 7/49 (14%), P < 0.001] but not in the 32-fraction cohort (P = 0.355). Grade 2+ gastrointestinal toxicity was highest for gemcitabine, with evidence of significant differences across therapies in the 32-fraction cohort (P = 0.006), with a similar pattern but no significant differences in the 20-fraction cohort (P = 0.099). There was no evidence of differences in grade 2+ genitourinary toxicity between concomitant therapies in either the 20- or 32-fraction cohorts. ConclusionGrade 2+ acute adverse events are common. The toxicity profile varied by type of concomitant therapy; the gastrointestinal toxicity rate seemed to be higher in patients receiving gemcitabine.

Challenges of food security in the Gulf Cooperation Council countries: an empirical analysis of fixed and random effects

Purpose. This research aims to identify the challenges of the food security indicators in the Gulf Cooperation Council (GCC) countries for the period 2000–2020.&#x0D; Methodology / approach. The dataset of this study includes the annual secondary data covering the time 2000–2019 of the six GCC countries. The dependents variables represent the food security indicators whereas, the independents variables (explanatory) represent the challenging factors of the food security at the macro-level data. All the studied variables are reshaped in the balanced panel form; thus, the study uses a long panel, it has many periods (T = 20 years) but few entities (n = 6 countries of GCC) with the total 120 observation. The study applies three alternatives to panel data analysis. &#x0D; Results. The results show that population is a significant driver of food security challenges in the GCC countries. Moreover, food price inflation has a significant impact on the food availability and stability but show no significance on food access and utilization. Fertilizer consumption causes significant problems with food use. The results show that there is an evidence of significant differences in food security across the GCC countries. The random-effects estimators of regression coefficients of food availability and stability challenges are more statistically efficient than those for pooled ordinary least square and fixed effects. While the fixed effects estimators are most preferred for the coefficients of food access and utilization challenges.&#x0D; Originality / scientific novelty. Most scientific articles are mostly focused on examining the food security challenges from one separate aspect: economics, climate, or social aspects. Thus, the scientific novelty of the study is to investigate the combination of the food security challenges, social, economic, and agri-environmental factors in the GCC oil countries. &#x0D; Practical value / implications. Through this research, it is proposed that decision-makers embark on interferences that stimulate food security to meet the continual increase in population also future research should be applied to the other factors that challenged food security.

Rapid upskilling about COVID-19 vaccines: an evaluation of a novel interprofessional education workshop.

An inter-professional education (IPE) workshop centred around newly approved COVID-19 vaccination was attended by 77 nursing and pharmacy students. To embed and evaluate the implementation of a virtual IPE workshop, and to upskill undergraduate nursing and pharmacy students about the COVID-19 vaccination. The workshop was evaluated using a questionnaire completed by participants from both disciplines. A focus group was conducted with the IPE facilitators. 77 students out of a potential 400 attended the workshop (19% attendance). Of the 77 participants, 44 (23 nursing, 21 pharmacy) completed the questionnaire (57%), rating the content highly. There was overall positivity toward working interprofessionally, and there was no evidence of significant differences between how the two groups of students rated the workshop. Qualitative findings from students and facilitators corroborated the supposition that the workshop would enhance professional development. Thus, the workshop was successful in facilitating interprofessional interactions, with students all working collaboratively toward the same goal, the ultimate purpose of IPE. It was agreed that such an event should be included as part of the student curricula. Implementing an IPE event that includes real-time healthcare priorities can contribute to optimising students' healthcare education. More high-quality longitudinal research is needed to understand the impact of such sessions on students' competence and confidence.

Systematic Review and Meta-Analysis: Association between Preoperative Ustekinumab and Surgical Complications in Crohn’s Disease Patients

Introduction: The impact of ustekinumab (UST) therapy on surgical complications in patients with Crohn’s disease (CD) remains controversial. The aim of this meta-analysis is to explore the link between these two. Methods: Databases (PubMed, Web of Science, Cochrane, and Springer Link) were searched until April 2022. Studies of CD patients who received UST and no UST prior to surgery (including no biological therapy, anti-tumor necrosis factor-α [anti-TNF-α] agent, and vedolizumab [VDZ]) were included. Primary outcomes included overall complications, infectious complications, and noninfectious complications. Results: Nine studies totaling 3,225 CD patients were enrolled; 332 patients received UST treatment. There was no evidence of difference in the overall complications (odds ratio [OR] = 0.84, p = 0.37, 95% confidence interval [CI] = [0.57–1.23], I² = 40%) between CD patients who had UST treatment preoperatively and those who had no UST treatment. There was no evidence of a difference in infectious complications (OR = 1.15, p = 0.35, 95% CI = [0.86–1.53], I² = 2%). Additionally, there was no significant evidence of difference between these groups in terms of noninfectious complications and death. Specifically, there was no evidence of difference in overall complications, infection complications (including wound complications, sepsis, abscess, and anastomotic leakage), and noninfection complications (ileus, readmission, and return to operation), compared with no biological therapy and anti-TNF-α agents. At the same time, no significant evidence of difference was discovered in the comparison of preoperative UST and VDZ therapy in terms of overall complications, infectious complications (sepsis and abscess), and noninfectious complications (intestinal obstruction, readmission, and recovery surgery). Conclusion: In general, compared with other biological agents, preoperative use of UST in the treatment of CD patients is usually safe and does not increase surgical complications.

RAPID METHOD FOR SIMULTANEOUS DETERMINATION OF CIS-9, TRANS-11 AND TRANS-10, CIS-12 CONJUGATED LINOLEIC ACID ISOMERS IN MILK BY GC-FID

Ruminant milk is the lead source of conjugated linoleic acid (CLA) in the human diet, with cis-9, trans-11 CLA being the major among all. Small amounts of trans-10, cis-12 CLA are also found in synthetic supplements. Since both isomers are biologically active with potential health benefits, there is great interest in quantifying them for quality control routines. An alternative method for the analysis of the aforementioned CLAs by fast gas chromatography (GC) is discussed in the present study. The fatty acid methyl ester mixture obtained by alkaline catalysis was injected into a GC equipped with a flame ionization detector (FID) and fitted with an ionic liquid SLB-IL111 chromatographic column (15 m × 0.10 mm × 0.08 µm). Separation was achieved in less than 5 min using a 168 °C isotherm run. Both CLA isomers were quantified by using of single point standard addition statistical approach. Results were contested to those obtained using the recommended 100 m long CP-Sil88 capillary column and none evidence of significant differences was found within 95% confidence interval. Therefore, the proposed method could be valuable to focused regulatory routines of large numbers of samples with greater analytical frequency.

Feasibility and usefulness of brain imaging in catatonia

Catatonia is a well characterized psychomotor syndrome that has recognizable motor, affective, behavioural and vegetative manifestations. Despite recent demonstration that catatonia is often associated with brain imaging abnormalities, there is currently no consensus or guidelines about the role of brain imaging. In this study, we assessed the feasibility of brain imaging in a series of patients with catatonia in a routine clinical setting and estimated the prevalence of clinically relevant radiological abnormalities.Sixty patients with catatonia were evaluated against sixty non-healthy controls subjects with headache. The MRI reports were reviewed, and MRI scans were also interpreted by neuroradiologists using a standardised MRI assessment.In this cohort, more than 85% of brain scans of patients with catatonia revealed abnormalities. The most frequently reported abnormalities in the catatonic group were white matter abnormalities (n = 44), followed by brain atrophy (n = 27). There was no evidence for significant differences in the frequency of abnormalities found in radiology reports and standardised neuroradiological assessments. The frequency of abnormalities was similar to that found in a population of non-healthy controls subjects with headache.This study shows that MRI is feasible in patients with catatonia and that brain imaging abnormalities are common findings in these patients. Most frequently, white matter abnormalities and diffuse brain atrophy are observed.